主題演講

藥物化學學會是為了在製藥、生物技術和學術領域工作的藥物和生物物理化學家所舉辦的一個充滿活力的會議。這是為數不多的專注於小分子候選藥物的發現和優化課題的國際活動之一。

藥物化學學會將於 4 月 2 日星期二下午 4:20 - 5:15（太平洋夏令時間）和 4 月 4 日星期四上午 8:30 - 9:20（太平洋夏令時間）舉辦全體主題演講。 每場講座可容納數百人參加，並設有與聽眾問答的時間，歡迎前來參加。

PLENARY KEYNOTE SESSION - TUESDAY AFTERNOON

4:30 pm Applications of SuFEx Click Chemistry for Drug Discovery and Chemical Biology
Barry Sharpless, PhD, Professor, Chemistry, Scripps Research Institute; 2022 and 2001 Nobel Laureate
My work has been guided by the modular simplicity of nature-the fact that all molecules of life are made from several dozen building blocks. Here I will discuss the Sulfur(VI) Fluoride Exchange (SuFEx), a second near-perfect click chemistry reaction pioneered here at Scripps. SuFEx allows reliable molecular connections to be made under metal-free conditions. I will include applications in drug discovery, chemical biology, and polymer chemistry.

Dr. Sharpless's >50-year research career has been devoted to finding new tools and better general methods for exploring the chemical universe. He shared the 2001 Nobel Prize in Chemistry for his work on chirally catalyzed oxidation reactions. In 2022, Barry was awarded the Nobel Prize in Chemistry for developing 'click chemistry', making him only the second scientist to win two Nobels in Chemistry. Click chemistry, a discovery methodology based on the insight that the molecules of life are made from less than several dozen small building blocks, provides a reliable way to uncover useful chemical function and spring-loaded ‘perfect’ reactions.

Today the focus of the Sharpless lab is Sulfur(VI) fluoride exchange (SuFEx) click chemistry, which allows reliable molecular connections under metal-free conditions. SuFEx has applications in synthetic methodology; chemical biology and drug discovery; and polymers and material science. Barry received his BA from Dartmouth College in 1963 and his PhD in Chemistry from Stanford University in 1968. Before joining Scripps Research in 1990, he was chemistry faculty at MIT and Stanford.

PLENARY KEYNOTE SESSION - THURSDAY MORNING

8:35 am Reimagining Druggability Using Chemoproteomic Platform
Daniel Nomura, PhD, Professor of Chemical Biology and Molecular Therapeutics, Department of Chemistry, University of California, Berkeley
One of the greatest challenges that we face in discovering new disease therapies is that most proteins are considered “undruggable,” in that most proteins do not possess known binding pockets or “ligandable hotspots” that small molecules can bind to modulate protein function. Our research group addresses this challenge by applying chemoproteomic platforms to discover and pharmacologically target unique and novel ligandable hotspots for disease therapy.

Dan Nomura is a professor in the Departments of Chemistry, Molecular and Cell Biology, and Nutritional Sciences and Toxicology at the University of California, Berkeley and an adjunct professor in the Department of Pharmaceutical Chemistry at UCSF. He is also the director of the Novartis-Berkeley Center for Proteomics and Chemistry Technologies and an Investigator in the Innovative Genomics Institute. He earned his BA in Molecular and Cell Biology and PhD in Molecular Toxicology at UC Berkeley with Professor John Casida and was a postdoctoral fellow at The Scripps Research Institute with Professor Ben Cravatt before returning to Berkeley as a faculty member in 2011. Among his honors are selection as a Searle Scholar, American Cancer Society Research Scholar Award, the Department of Defense Breakthroughs Award, and the Mark Foundation for Cancer Research ASPIRE Award. The Nomura Research Group is focused on redefining druggability using chemoproteomic platforms to tackle the undruggable proteome.